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It is only natural to assume that an overdose with an agent used to treat diabetes will result in very low blood sugar. This is certainly true with insulin and sulfonylurea agents such as glipizide or glyburide, but it is not the case with metformin overdose. Metformin is one of the most commonly prescribed drugs in the world, used as a first-line treatment for Type 2 diabetes and many off-label indications such as polycystic ovary syndrome, obesity, and antipsychotic-induced weight gain.

It should come as no surprise that bupropion (Wellbutrin®, Aplenzin®, formerly Zyban®, others) can cause serious symptoms in overdose. It is used to treat depression and to reduce cravings in smoking cessation, obesity, and other substance use disorders.